HYPOGAMMAGLOBULINEMIA OF INFANCY - 03/09/11

Doi : 10.1016/S0889-8561(05)70196-X

Ilan Dalal, MD ^{^{*
Infectious, Allergy and Immunology Unit, Department of Pediatrics, E. Wolfson Medical Center and the Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel (ID); and Division of Immunology and Allergy, Department of Paediatrics, and Infection, Immunity, Injury, and Repair Program, Research Institute at the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (CMR)}}, Chaim M. Roifman, MD, FRCPC, FCACB ^{^{*
Infectious, Allergy and Immunology Unit, Department of Pediatrics, E. Wolfson Medical Center and the Sackler Faculty of Medicine, University of Tel Aviv, Tel Aviv, Israel (ID); and Division of Immunology and Allergy, Department of Paediatrics, and Infection, Immunity, Injury, and Repair Program, Research Institute at the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (CMR)}}

Résumé

In their classic report from 1956, Gitlin and Janeway^{16 Gitlin D., Janeway C.A. Agammaglobulinemia: Congenital, acquired and transient forms Prog Hematol 1956 ; 1 : 318

Cliquez ici pour aller à la section Références} first coined the term transient hypogammaglobulinemia of infancy (THI). Although THI has been recognized for many years and despite significant progress in understanding the molecular basis and identifying the genes involved in the pathogenesis of many other forms of humoral immunodeficiencies (ID), little is known about this specific entity. This article summarizes previous studies and reports our long-term experience with THI.

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