Survival after first esophageal variceal hemorrhage in patients with biliary atresia - 02/09/11
Abstract |
Objective: To determine the influence of the new onset of esophageal variceal hemorrhage (EVH) on transplant-free survival in children with biliary atresia and to examine variables that predicted survival after the onset of EVH. Methods: Retrospective chart review of 134 patients with biliary atresia who underwent portoenterostomy between 1973 and 1992 at a single institution; 29% had EVH. Results: The risk of death or need for liver transplantation was 50% at 6 years after the initial episode of EVH. Patients with a serum bilirubin concentration ≤4 mg/dL at the first episode of EVH had transplant-free survival of >80% for 4 years after this episode, those with bilirubin levels >4 to 10 mg/dL had 50% survival at 1 year, and those with bilirubin levels >10 mg/dL had 50% survival at 4 months. The risk of death or transplant for a child with EVH and total serum bilirubin levels >10 mg/dL was 12.0 (95% CI: 6.0, 24.1), 4 to 10 mg/dL was 7.2 (3.1, 16.7), and ≤4 mg/dL was 0.6 (0.1, 3.1) times the risk of a same-aged child who did not have EVH. Conclusions: Children with biliary atresia and first EVH episode have a variable prognosis related to total serum bilirubin concentration at the time of the episode. (J Pediatr 2001;139:291-6)
Le texte complet de cet article est disponible en PDF. Supported in part by National Institutes of Health grant 5MO1 RR00069 from General Clinical Research Centers Program of the National Center for Research Resources, National Institutes of Health, and the Abbey Bennett Liver Research Fund. |
Vol 139 - N° 2
P. 291-296 - août 2001 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?