There is a substantial amount of published work describing how to help patients and families deal with stress, grief, and loss, but there is much less advice available for clinicians dealing with similar issues. Working as an oncologist is inherently difficult, and racked by emotional and psychological traumas. However, it can also be tremendously rewarding. In this review, I discuss the extent of stress and burnout in the practice of oncology, its causes and manifestations, and strategies for overcoming it.