Rv1773 is a transcriptional repressor deleted from BCG-Pasteur - 01/09/11
Doi : 10.1016/j.tube.2007.05.016
David C. Alexander, Marcel A. Behr ⁎ 
McGill University Health Centre, McGill University, Montreal, Que., Canada H3G 1A4
Corresponding author. Division of Infectious Diseases and Medical Microbiology, A5–156, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Que., Canada H3G 1A4. Tel.: +15149341934x42815; fax: +15149348423.Summary |
Mycobacterium bovis Bacille Calmette-Guérin (BCG) is a live attenuated vaccine for the prevention of tuberculosis. Transcriptome comparison reveals dysegulated expression of two genes, Rv1774 and Rv1775, exclusively in the Pasteur strain of BCG. We show that these genes form a bicistronic operon regulated by Rv1773, a transcriptional repressor deleted during the in vitro evolution of BCG.
Le texte complet de cet article est disponible en PDF.KEYWORDS : Tuberculosis, BCG, Gene expression, Transcriptional regulation
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© 2007
Elsevier Ltd. Tous droits réservés.
Vol 87 - N° 5
P. 421-425 - septembre 2007 Retour au numéro
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