Plasma adenosine concentration increases during exercise: A possible contributing factor in exercise-induced bronchoconstriction in asthma - 01/09/11
Abstract |
We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 ± 35 vs 59 ± 16 nmol/L; P < .001). In patients with asthma, the increase in ADO was related to decreases in FEV1 (r 2 = 0.475; P < .05) and SaO2 (r 2 = 0.693; P < .05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction. (J Allergy Clin Immunol 2002;109:446-8.)
Le texte complet de cet article est disponible en PDF.Keywords : Exercise-induced bronchoconstriction, adenosine, asthma
Abbreviations : ADO:, EIB:, HXN:, INO:, SaO2:
Plan
 | Supported by the Hungarian National Scientific Research Fund (OTKA T-030340) and the Hungarian Allergy and Clinical Immunology Society (MAKIT). |
| Reprint requests: Éva Huszár, PhD, National Korányi Institute for Tuberculosis and Pulmonology, Department of Pathophysiology, Budapest Pihenõ u.1. PO Box 1, H-1529, Hungary. |
Vol 109 - N° 3
P. 446-448 - mars 2002 Retour au numéro
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