Markers of oxidative injury in the cerebrospinal fluid of a premature infant with meningitis and periventricular leukomalacia - 01/09/11
Doi : 10.1067/mpd.2002.123627
Terrie Inder, MD, Tessa Mocatta, MSc, Brian Darlow, MD, Carole Spencer, Revathy Senthilmohan, PhD, Christine C. Winterbourn, PhD, Joseph J. Volpe, MD
From the Murdoch Children's Research Institute and Howard Florey Institute, Royal Women's Hospital, and Royal Children's Hospital, Melbourne, Australia; Departments of Pediatrics and Pathology, Christchurch School of Medicine and Health Sciences, New Zealand; and Department of Neurology, Children's Hospital, and Harvard Medical School, Boston, Massachusetts.
Abstract |
Free radicals have been hypothesized to play a key role in the evolution of periventricular leukomalacia, although direct evidence of oxidative injury in the human infant is lacking. This case report is the first to demonstrate a marked elevation in the levels of lipid and protein oxidative products in the cerebrospinal fluid during the evolution of periventricular leukomalacia in a premature infant with meningitis. (J Pediatr 2002;140:617-21)
Le texte complet de cet article est disponible en PDF. | Supported by grants from the Neurological Foundation of New Zealand, Health Research Council of New Zealand, and Lottery Health of New Zealand. |
© 2002
Mosby, Inc. Tous droits réservés.
Vol 140 - N° 5
P. 617-621 - mai 2002 Retour au numéro
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