Paraneoplastic acral vascular syndrome: Epidemiologic features, clinical manifestations, and disease sequelae - 01/09/11
Abstract |
Background: Acral vascular syndromes associated with malignancy have rarely been reported. Objective: Our purpose was to assess the clinical and evolving features of paraneoplastic acral vascular syndromes. Patients and Methods: Two cases of paraneoplastic gangrene are described and analyzed together with previously reported cases identified by a MEDLINE search. Results: Among the 68 patients identified, 40 had gangrene, 16 had acrocyanosis, and 12 had Raynaud's phenomenon. The male to female ratio was 0.89; median age was 59 years. Fingers were affected in 94%. Adenocarcinomas were the predominant associated malignancies (41%), and metastases were observed in 41%. The acral vascular syndromes in 48% of the patients definitively regressed after tumor treatment. Forty-four percent of the patients died within 2 years. A favorable cutaneous outcome was obtained with prostacyclin infusions in 6 patients. Conclusion: A neoplastic origin of acral vascular syndrome should be considered in elderly patients, especially men, in the absence of usual causative conditions. (J Am Acad Dermatol 2002;47:47-52.)
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![]() | Funding source: None. |
![]() ![]() | Conflict of interest: None. |
![]() | Reprint requests: Manuelle Viguier, Service de Dermatologie1, Hôpital Saint-Louis, 1 avenue Claude-Vellefaux, 75475 Paris Cedex 10, France. |
Vol 47 - N° 1
P. 47-52 - juillet 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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