Prostaglandin E2 induces vasodilation and pruritus, but no protein extravasation in atopic dermatitis and controls - 01/09/11
Abstract |
Background: Prostaglandin E2 (PGE2) has well-established vasodilatory effects, whereas its effects on protein extravasation and its sensory effects are less clear. Objective: Vasoactive effects of PGE2 were correlated to its ability to evoke pain or itch in healthy volunteers and patients with atopic dermatitis (AD). Methods: Intradermal microdialysis was used to apply PGE2 (10−8-10−4 M) via microdialysis capillaries in 8 patients and 8 controls. Large pore size membranes (3000 kd) enabled simultaneous analysis of protein extravasation. Itch and pain sensations were measured psychophysically, and superficial blood flow was measured by laser Doppler imaging. Results: PGE2 dose dependently provoked intense local vasodilation, weak pruritus, and pain, but no protein extravasation. No differences were found between patients with AD and controls for any parameter. Conclusion: We conclude that PGE2 is a potent vasodilator and a weak pruritic agent in normal skin and in patients with AD, but does not provoke increased protein extravasation. (J Am Acad Dermatol 2002;47:28-32.)
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 | Supported by the EADV/Yamanouchi Europe Dermatology Research Fellowship and the Deutsche Forschungsgemeinschaft (SFB 353). |
| Reprint requests: PD Dr. med. M. Schmelz, Institut für Physiologie und Experimentelle Pathophysiologie, Universitätsstr 17, 91054 Erlangen, Germany. |
Vol 47 - N° 1
P. 28-32 - juillet 2002 Retour au numéro
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