Oral contraceptive efficacy and antibiotic interaction: A myth debunked - 01/09/11
Abstract |
The purpose of this study was to review the pharmacokinetic and clinical literature regarding the efficacy of oral contraceptives when used concomitantly with antibiotic therapy. Relevant literature was identified by searching MEDLINE and EMBASE. Other sources were located by consulting the bibliographies of the material collected from MEDLINE and EMBASE. Pharmacokinetic evidence demonstrates that plasma levels of oral contraceptive steroids are unchanged with the concomitant administration of antibiotics, including ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline. However, reduced steroid levels have been reported in women taking rifampin with oral contraceptives. Clinical reports of contraceptive failure with antibiotic use are retrospective, have multiple potential biases, and are not supported by pharmacokinetic data. Available scientific and pharmacokinetic data do not support the hypothesis that antibiotics (with the exception of rifampin) lower the contraceptive efficacy of oral contraceptives. (J Am Acad Dermatol 2002;46:917-23.)
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![]() | Funding sources: None. |
![]() ![]() | Disclosure: David F. Archer, MD, has received grants for clinical trials from Wyeth-Ayerst Laboratories, Ortho Pharmaceutical, Organon, Inc, Lilly, Schering Plough, Berlex Laboratories, Pharmacia Corp, and TAP; he is a consultant to Wyeth-Ayerst Laboratories, TAP, Organon, Inc, Lilly, Pharmacia Corp, and Schering Plough; and he serves on the speakers' bureaus of Wyeth-Ayerst Laboratories, Organon, Inc, Pharmacia Corp, and Lilly. |
![]() | Reprint requests: Johanna S. M. Archer, MD, Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas St, Suite 634, Charleston, SC 29425. |
Vol 46 - N° 6
P. 917-923 - juin 2002 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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