Rash severity in herpes zoster: Correlates and relationship to postherpetic neuralgia - 01/09/11
Abstract |
Baseline and follow-up data from 4 samples of immunocompetent patients with herpes zoster who participated in clinical trials of the antiviral agent famciclovir were examined (N = 1778). In both univariate and multivariate analyses, severe rash (ie, >50 lesions, defined as papules, vesicles, or crusted vesicles) was significantly associated with older age, male sex, severe pain, primary involvement of nontrigeminal dermatomes, and a greater number of affected dermatomes. In addition, severe rash predicted the presence of pain 3 months later. The results indicate that severe rash is more common in patients with herpes zoster who are older and who have more severe acute pain and confirm that severe rash is a risk factor for prolonged pain. (J Am Acad Dermatol 2002;46:834-9.)
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 | Funding sources: Data collection was sponsored by SmithKline Beecham Pharmaceuticals. Data analyses were supported by a grant from SmithKline Beecham Pharmaceuticals (to R. H. D.). |
| Disclosure: Robert W. Johnson, MB, and Robert H. Dworkin, PhD, have received research grants from and served as members of speakers' bureaus and advisory boards for Glaxo Wellcome and SmithKline Beecham Pharmaceuticals. David R. J. Griffin was employed by SmithKline Beecham Pharmaceuticals and is currently employed by GlaxoSmithKline. |
 | Reprint requests: Robert H. Dworkin, PhD, Department of Anesthesiology, University of Rochester Medical Center, 601 Elmwood Ave, Box 604, Rochester, NY 14642. |
Vol 46 - N° 6
P. 834-839 - juin 2002 Retour au numéro
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