Decreased IFN- γ and increased IL-4 production by human CD8+ T cells in response toMycobacterium tuberculosis in tuberculosis patients - 01/09/11
Abstract |
To investigate the role of MHC class I restricted CD8+ T cells in host defense to M. tuberculosis, peripheral blood mononuclear cells (PBMC) from healthy BCG-vaccinated donors and untreated pulmonary tuberculosis (TB) patients in The Gambia were stimulated for 6 days with M. bovis BCG or M. tuberculosis and the CD8+ T cell response analyzed. Intracellular FACS analysis of cytokine production by CD8+ T cells showed that IFN- γ and TNF- ⍺ production were greatly reduced in TB patients compared to healthy controls. IL-4-producing CD8+ T cells were detected in TB patients, a phenotype absent in controls. Collectively, these data suggest that an alteration in the type 1/type 2 cytokine balance occurs in CD8+ T cells during clinical tuberculosis, and that this may provide a surrogate marker for disease.
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Vol 82 - N° 1
P. 7-13 - février 2002 Retour au numéro
Article précédent
- A variable number of tandem repeats result in polymorphic ⍺ -isopropylmalate synthase inMycobacterium tuberculosis
- W. Chanchaem, P. Palittapongarnpim
- Increased protection against bovine tuberculosis in the brushtail possum (Trichosurus vulpecula) when BCG is administered with killed Mycobacterium vaccae
- M.A. Skinner, D.L. Keen, N.A. Parlane, G.F. Yates, B.M. Buddle
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