Prednisolone in the treatment of adrenal insufficiency: a re-evaluation of relative potency - 29/08/11
Doi : 10.1067/S0022-3476(03)00294-4
Zubin Punthakee, MD, Laurent Legault, MD, Constantin Polychronakos, MD ⁎ 
From Endocrinology and Metabolism, and Pediatric Endocrinology and Metabolism, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Reprint requests: Constantin Polychronakos, MD, Montreal Children's Hospital Room C-244, 2300 Tupper St, Montreal, Quebec, H3H 1P3, Canada.Abstract |
Prednisolone has unknown growth-suppressing effects relative to other steroids. We retrospectively studied 9 children (6 with congenital adrenal hyperplasia, CAH) receiving hydrocortisone replacement after switching to prednisolone (dose ratio, 1:5). Growth velocity and, in patients with CAH, 17-OHP decreased significantly. Dose reduction reversed these effects. Roughly, growth suppression relative potency for prednisolone:hydrocortisone was 15:1.
Le texte complet de cet article est disponible en PDF.Abbreviations : CAH, HPA axis, 17-OHP
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Vol 143 - N° 3
P. 402-405 - septembre 2003 Retour au numéro
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