Decreased energy expenditure is caused by abnormal body composition in infants with Prader-Willi Syndrome - 29/08/11
, Aaron L Carrel, MD, Timothy C Shriver, MS, Zhanhai Li, PhD, David B Allen, MD
Reprint requests: M. Tracy Bekx, MD, Department of Pediatric Endocrinology, University of Wisconsin Hospital and Clinics, 600 Highland Dr, Madison, WI 53792.Abstract |
Objective |
Infants with Prader-Willi syndrome (PWS) are hypotonic and underweight before the onset of childhood obesity. This study evaluates body composition in the PWS infant and its relationship to energy expenditure.
Study design |
Sixteen infants and toddlers with PWS (mean age, 12.4±6 months; eight female subjects) underwent analysis of body composition with dual-energy x-ray absorptiometry and deuterium dilution, and energy expenditure with both doubly labeled water and indirect calorimetry.
Results |
Percent body fat was significantly increased (male subjects, P<.001; female subjects, P<.001) and fat-free mass (FFM) was significantly decreased (male subjects, P<.001; female subjects, P=.04) in infants with PWS when compared with age-matched published data for normal infants. Meanwhile, total energy expenditure was significantly decreased (male subjects, P=.025; female subjects, P<.001) in infants with PWS when compared with published normative data. There was a normal relationship between FFM and total energy expenditure in infants with PWS.
Conclusion |
Compared with published data for infants without PWS, infants with PWS demonstrate increased percent body fat, decreased FFM, and decreased energy expenditure. Importantly, total energy expenditure per kilogram of FFM appears similar in infants with and without PWS. We conclude that lower energy expenditure in infants with PWS is caused by decreased FFM.
Le texte complet de cet article est disponible en PDF.Abbreviations : DD, DXA, DLW, EE, GH, FFM, IC, PWS, TEE
Plan
 | Supported by grants from the National Institutes of Health (#M01 RR033186) and Pharmacia. |
Vol 143 - N° 3
P. 372-376 - septembre 2003 Retour au numéro
Article précédent
- Three-Year prevalence and incidence of diabetes among American Indian youth in Montana and Wyoming, 1999 to 2001
- Kelly R. Moore, Todd S. Harwell, Janet M. McDowall, Steven D. Helgerson, Dorothy Gohdes
- A randomized, placebo-controlled trial of the effect of antihistamine or corticosteroid treatment in acute otitis media
- Tasnee Chonmaitree, Kokab Saeed, Tatsuo Uchida, Terho Heikkinen, Constance D Baldwin, Daniel H Freeman, David P McCormick
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?