Immune mechanisms leading to atopic dermatitis - 29/08/11

Doi : 10.1016/j.jaci.2003.09.032

Natalija Novak, MD ^a,^{^{1
Dr Novak has no conflict of interest to disclose.}}, Thomas Bieber, MD, PhD ^a,^{^{2
Dr Bieber has no conflict of interest to disclose.}}, Donald Y.M Leung, MD, PhD ^b,^⁎,^{^{3
Dr Leung is a consultant to Novartis, has received research support/grants from Novartis, and is a member of the speakers' bureau.}}
^a Department of Dermatology, University of Bonn, Bonn, Germany
^b Division of Allergy and Immunology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colo, USA

Reprint requests: Donald Y. M. Leung, MD, PhD, National Jewish Medical and Research Center, Department of Pediatrics, Room K926, 1400 Jackson St, Denver, CO 80206

Abstract

The incidence of atopic dermatitis is increasing, and this poses a major burden on health care costs. A precise understanding of the genetic and immunologic mechanisms is crucial for development of effective treatment strategies for atopic dermatitis. Various studies indicate that it has a multifactorial cause, with activation of complex immunologic and inflammatory pathways. The current review will examine recent advances that have been made in our understanding of the genetic and pathophysiologic prerequisites that form the basis of this common recalcitrant skin disorder.

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Keywords : Atopic dermatitis, dendritic cells, IgE, inflammation, skin

Abbreviations : AD, APC, APT, CLA, IDEC, LC, PG, SNP, SP