The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes - 29/08/11
Correspondence: Dr Lindsay Brown, Department of Physiology and Pharmacology, School of Biomedical Sciences, The University of Queensland, Queensland 4072, Australia.Abstract |
Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes is streptozotocin (STZ)-induced diabetes in the rat.
Methods: This project assessed cardiovascular, ocular and neuropathic changes over a period of 24 weeks post STZ administration in rats.
Results: STZ-diabetic rats (n = 96) showed stable signs of diabetes (hyperglycaemia, increased water and food intake with no increase in bodyweight): 52% of untreated STZ-diabetic rats (n = 50) survived 24 weeks after STZ administration. STZ-diabetic rats were normotensive with slowly developing systolic and diastolic dysfunction and an increased ventricular stiffness. Ventricular action potential durations were markedly prolonged. STZ-diabetic rats developed stable tactile allodynia. Cataracts developed to presumed blindness at 16 weeks but proliferative retinopathy was not observed even after 24 weeks.
Conclusion: The chronic STZ-diabetic rat mimics many but not all of the chronic complications observed in the diabetic human. The chronic STZ-diabetic rat may be a useful model to test therapeutic approaches for amelioration of chronic diabetic complications in humans.
Le texte complet de cet article est disponible en PDF.Keywords : cataracts, diabetes, echocardiography, electrophysiology, neuropathic pain, retinopathy
 | Presented at the International Society for Heart Research and International Union of Physiological Societies World Congress Satellite Meeting, Models of Cardiovascular Disease, 2–4 September 2001, Brisbane, Australia. |
Vol 12 - N° 1
P. 44-50 - 2003 Retour au numéro
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