Interleukin-6 promoter −174 polymorphism and spontaneous preterm birth - 28/08/11
, Marijane A Krohn, PhD a, James M Roberts, MD a, Adriana Zeevi, PhD b, Steve N Caritis, MD a
Reprint requests: Hyagriv N. Simhan, MD, 300 Halket St, Pittsburgh, PA 15213.Abstract |
Objective |
We assessed the relationship between interleukin-6 (IL-6) promoter −174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race.
Study design |
Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.
Results |
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (P<.001)
Conclusion |
The IL-6 promoter −174 allelic variant C/C is significantly less frequent among women with sPTB less than 34 weeks. There is a dramatic racial disparity in the distribution of allelic variants of this polymorphism.
Le texte complet de cet article est disponible en PDF.Keywords : Interleukin-6, cytokine promoter polymorphism, preterm birth
Plan
 | Support provided by 2PO1 HD 30367-09 and 5MO1 RR 00056 and 1K12 HD 01261. |
Vol 189 - N° 4
P. 915-918 - octobre 2003 Retour au numéro
Article précédent
- Interleukin-1 receptor antagonist gene polymorphism and multifetal pregnancy outcome
- Robin B Kalish, Santosh Vardhana, Meruka Gupta, Stephen T Chasen, Sriram C Perni, Steven S Witkin
- The clinical significance of detecting Ureaplasma urealyticum by the polymerase chain reaction in the amniotic fluid of patients with preterm labor
- Bo Hyun Yoon, Roberto Romero, June-Hee Lim, Soon-Sup Shim, Joon-Seok Hong, Jae-Yoon Shim, Jong Kwan Jun
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?