Monocyte chemotactic protein-1 in cervical and amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation, and preterm delivery - 28/08/11
, Rose-Marie Holst, MD a, Ulla-Britt Wennerholm, MD, PhD a, Bengt Andersson, MD, PhD b, Håkan Lilja, MD, PhD a, Henrik Hagberg, MD, PhD a
Reprints not available from the authors. Corresponding author: Bo Jacobsson, MD, PhD, Department of Obstetrics and Gynecology, Sahlgrenska University Hospital/East, SE-416 85 Göteborg, Sweden.Göteborg, Sweden
Abstract |
Objective |
The purpose of this study was to evaluate the role of monocyte chemotactic protein-1 in cervical and amniotic fluid in women in preterm labor and with preterm premature rupture of membranes.
Study design |
Women with singleton pregnancies (≤34 weeks) in preterm labor (n=75 women), with preterm premature rupture of membranes (n=47 women), and at term (n=45 women) who were undergoing elective cesarean delivery were included. Cervical and amniotic fluid were sampled.
Results |
Monocyte chemotactic protein-1 in cervical and amniotic fluid was higher in women in preterm labor than in women at term. Cervical monocyte chemotactic protein-1 in women in preterm labor was associated with microbial invasion of the amniotic cavity, intra-amniotic inflammation, delivery within 7 days, and at ≤34 weeks. Amniotic monocyte chemotactic protein-1 correlated to microbial invasion of the amniotic cavity in women with preterm premature rupture of membranes, intra-amniotic inflammation in preterm labor, preterm premature rupture of membranes, delivery within 7 days, and delivery at ≤34 weeks in women in preterm labor.
Conclusion |
Monocyte chemotactic protein-1 in cervical and amniotic fluid levels are elevated in preterm labor and preterm premature rupture of membranes and correlate to intra-amniotic infection/inflammation.
Le texte complet de cet article est disponible en PDF.Keywords : Monocyte chemotactic protein-1, amniotic fluid, cervical fluid, preterm birth
Plan
 | Supported by the Swedish Medical Research Council (09455), the Göteborg Medical Society, and the Frimurare Barnhus Foundation and by Swedish government grants to researchers in public health service (ALF). |
Vol 189 - N° 4
P. 1161-1167 - octobre 2003 Retour au numéro
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