Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects - 28/08/11
, Peter L Zock, PhD a, Cees A Swenne, PhD c, Ingeborg A Brouwer, PhD a, Evert G Schouten, PhD a, b, Martijn B Katan, PhD a, bAbstract |
Background |
N-3 fatty acids may reduce the risk of sudden death by preventing life-threatening cardiac arrhythmias. Heart rate variability (HRV) and baroreflex sensitivity (BRS) reflect cardiac autonomic regulation; reduced values predict arrhythmic events and mortality. Effects of n-3 fatty acids on these risk indicators of arrhythmia have not been widely studied. We investigated the effect of supplemental intake of n-3 fatty acids on HRV and BRS in apparently healthy subjects aged 50 to 70 years.
Methods |
After a run-in period of 4 weeks, 84 subjects were randomized to receive capsules with either 3.5 g of fish oil or placebo oil daily for 12 weeks. Before and after intervention, electrocardiograms and blood pressure were recorded for 10 minutes with standardized respiration of 15 breaths/min. The SD of the duration of all normal RR intervals (SDNN10) and the root mean square successive differences (RMSSD10) were calculated from the 10-minute recordings. We also computed low frequency power (LF) and high frequency power (HF). BRS was computed by integrating the spectral systolic blood pressure to interbeat-interval transfer function in the 0.05- to 0.15-Hz band.
Results |
The different measures of HRV and BRS did not significantly improve with the intake of n-3 fatty acids. SDNN10 decreased by 3.05 ms or 7.7% (95% CI, −8.91-2.82 ms), and BRS decreased by 0.92 ms/mm Hg or 0.1% (95% CI, −2.66-0.81 ms/mm Hg) in the fish oil group compared with the placebo group.
Conclusions |
N-3 fatty acids have no effect on HRV from short-term recordings and BRS in apparently healthy subjects.
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 | Supported by the Wageningen Centre for Food Sciences, an alliance of major Dutch food industries, TNO Nutrition and Food Research, and Wageningen University and Research Centre, with financial support from the Dutch government. |
Vol 146 - N° 2
P. 344 - août 2003 Retour au numéro
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