Neutrophil granule products: can they identify subclinical chorioamnionitis in patients with preterm premature rupture of membranes? - 28/08/11
, R.Phillips Heine, MD
Reprint requests: Ian A. Grable, MD, MPH, 330 Brookline Ave, Boston, MA 02215.Abstract |
Objective |
Our purpose was to determine whether maternal plasma levels of neutrophil granule products are elevated in patients with chorioamnionitis after preterm premature rupture of membranes (PROM).
Study design |
Fifty-two patients between 24 and 34 weeks' gestation with preterm PROM were included. Plasma samples for defensins and lactoferrin were collected throughout latency. Fifty-two control subjects between 26 and 30 weeks' gestation were recruited for baseline levels.
Results |
Mean control defensin levels were compared with mean defensin levels on admission (668 ng/mL vs 5665 ng/mL, P<.01). Mean defensin levels on admission in patients without chorioamnionitis were compared with those of patients in whom histologic chorioamnionitis developed (520 ng/mL vs 9163 ng/mL, P<.01). The same relationships were not demonstrated for lactoferrin. With use a defensin value of 1500 ng/mL on admission, the sensitivity is 76% and specificity is 94% in predicting histologic chorioamnionitis.
Conclusions |
Maternal plasma levels of defensins are markers of histologic chorioamnionitis in patients after preterm PROM.
Le texte complet de cet article est disponible en PDF.Keywords : Premature rupture of membranes, defensins, lactoferrins, chorioamnionitis, latency, premature delivery
Plan
 | Presented at the Twenty-Third Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, Calif, February 3-8, 2003. |
Vol 189 - N° 3
P. 808-812 - septembre 2003 Retour au numéro
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