Duration of antibiotic therapy after preterm premature rupture of fetal membranes - 28/08/11
, Annette M Miles, MD, MPH, Bonnie Clothier, MSN, CRNP, Samuel Parry, MD, George A Macones, MD, MSCE
Reprint requests: Sally Y. Segel, MD, Atlanta Perinatal Consultants, Northside Hospital Department of Perinatology, 1000 Johnson Ferry Rd, Atlanta, GA 30342.Abstract |
Objective |
This study was undertaken to compare the efficacy of 3 days versus 7 days of ampicillin in prolonging gestation for at least 7 days in women with preterm premature rupture of membranes (PPROM).
Study design |
We performed a randomized clinical trial comparing 3 days of ampicillin with 7 days ampicillin in patients with PPROM. Our primary outcome was the prolongation of pregnancy for at least 7 days. Secondary outcomes included rates of chorioamnionitis, postpartum endometritis, and neonatal morbidity and mortality.
Results |
Forty-eight patients were randomly selected. There was no statistically significant difference in the ability to achieve a 7-day latency (relative risk 0.83, 95% CI 0.51-1.38). In addition, there was no statistically significant difference in the rates of chorioamnionitis, endometritis, and our composite neonatal morbidity.
Conclusion |
In patients with PPROM, length of antibiotic therapy does not change the rate of a 7-day latency or affect the rate of chorioamnionitis, postpartum endometritis, or neonatal morbidity.
Le texte complet de cet article est disponible en PDF.Keywords : Preterm premature rupture of membranes, latency, antibioitics
Plan
 | Presented at the Twenty-Third Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, Calif, February 3-8, 2003. |
Vol 189 - N° 3
P. 799-802 - septembre 2003 Retour au numéro
Article précédent
- Prolonged latency after preterm premature rupture of membranes: an evaluation of histologic condition and intracranial ultrasonic abnormality in the neonate born at <28 weeks of gestation
- Thomas F McElrath, Elizabeth N Allred, Alan Leviton, the Developmental Epidemiology Network Investigators
- Umbilical cord pH and base excess values in relation to neonatal morbidity for infants delivered preterm
- Rahi Victory, Deborah Penava, Orlando da Silva, Renato Natale, Bryan Richardson
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