Oral misoprostol for premature rupture of membranes at term - 28/08/11
, Tina Delaney, MD, Donna Hutchens, BN
Reprint requests: Joan M. G. Crane, Department of Obstetrics and Gynecology, Memorial University of Newfoundland, 300 Prince Phillip Dr, St John's, Newfoundland, Canada A1B 3V6.Abstract |
Objective |
The study was undertaken to compare the efficacy, safety, and maternal satisfaction of oral misoprostol and intravenous oxytocin for labor induction in women with premature rupture of membranes at term.
Study design |
One hundred five women were stratified by parity and randomly assigned to oral misoprostol 75 μg every 4 hours as needed to establish labor or to intravenous oxytocin.
Results |
The induction to vaginal delivery time with oral misoprostol was 737 (±426) minutes compared with 573 (±318) minutes with oxytocin (P=.04). The incidence of hyperstimulation was lower in the misoprostol group (6.0% vs 27.1%, P=.005). Women were more likely to be very satisfied with their care in the misoprostol group (86.0% vs 63.4%, P=.02).
Conclusion |
In women at term with premature rupture of membranes, oral misoprostol resulted in a longer induction to vaginal delivery interval but increased maternal satisfaction and less hyperstimulation compared with intravenous oxytocin. Further research is needed to assess uncommon neonatal and maternal outcomes.
Le texte complet de cet article est disponible en PDF.Keywords : Induction, misoprostol, premature rupture of membranes, randomized clinical trial
Plan
 | Supported by Memorial University of Newfoundland, Faculty of Medicine Operating Grant. Presented at the Twenty-Third Annual Meeting of the Society for Maternal-Fetal Medicine, San Francisco, Calif, February 3-8, 2003. |
Vol 189 - N° 3
P. 720-724 - septembre 2003 Retour au numéro
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