Collagen content and growth factor immunoexpression in uterine lower segment of type IA osteogenesis imperfecta: Relationship with recurrent uterine rupture in pregnancy - 28/08/11
, Fabrizio Pollio, MD a, Marianna De Falco, MD a, Francesca Iannotti, MD a, Massimo Mascolo, MD b, Pasquale Somma, MD b, Stefania Staibano, MD b
Reprint requests: Andrea Di Lieto, MD, Department of Obstetrical-Gynaecological and Urological Science and Reproductive Medicine, University “Fedrico II” of Naples, via S. Pansini 5, 80131 Naples, Italy.Abstract |
OBJECTIVE: The purpose of this study was to evaluate collagen content and platelet-derived growth factor, vascular endothelial growth factor, and connective tissue growth factor expression in the myometrium of the uterine lower segment from a patient with type IA osteogenesis imperfecta with recurrent uterine rupture and to evaluate the existence of a relationship between the rare recurrent uterine rupture and the tissue disorders of type IA osteogenesis imperfecta.
STUDY DESIGN: Collagen content and platelet-derived growth factor, vascular endothelial growth factor, and connective tissue growth factor expression in the uterine lower segment were assessed in the patient with type IA osteogenesis imperfecta and in eight otherwise healthy (“control”) patients.
RESULTS: Type IA osteogenesis imperfecta contained less total collagen amount, with no difference in type III collagen expression and showed increased levels of platelet-derived growth factor and vascular endothelial growth factor in myometrial smooth muscle cells. No difference was observed in connective tissue growth factor expression.
CONCLUSION: These findings confirm the diminished collagen amount in myometrium from osteogenesis imperfecta and show the presence of additional pathogenetic mechanisms. A relationship is hypothesized between the underlying myometrial biochemical modifications and the recurrent uterine rupture.
Le texte complet de cet article est disponible en PDF.Keywords : Osteogenesis imperfecta, immunohistochemistry, collagen, growth factor, uterine rupture
Plan
Vol 189 - N° 2
P. 594-600 - août 2003 Retour au numéro
Article précédent
- Elevated plasma endothelial microparticles in preeclampsia
- Vı́ctor H González-Quintero, Joaquı́n J Jiménez, Wenche Jy, Lucı́a M Mauro, Lawrence Hortman, Mary J O'Sullivan, Yeon Ahn
- Swallowing, urine flow, and amniotic fluid volume responses to prolonged hypoxia in the ovine fetus
- Ralph W Thurlow, Robert A Brace
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?