Helicobacter pylori infection and the occurrence and severity of gastrointestinal symptoms during pregnancy - 28/08/11
Reprint requests: Dietrich Rothenbacher, MD, Department of Epidemiology, The German Centre for Research on Ageing, D-69115 Heidelberg/Germany.Heidelberg and Ulm, Germany
Abstract |
OBJECTIVE: We investigated the possible role of Helicobacter pylori infection in the occurrence and severity of gastrointestinal symptoms during pregnancy in a large group of mothers after delivery.
STUDY DESIGN: Between November 2000 and November 2001, mothers were recruited after delivery at the Department of Gynecology and Obstetrics at the University of Ulm. Present H pylori infection was determined by 13C-urea breath test. Associations between gastrointestinal symptoms during pregnancy (sickness, vomiting, increased saliva production, heartburn) and H pylori infection were quantified by crude and adjusted odds ratios with 95% CI.
RESULTS: Twenty-three percent of the 898 mothers had a current H pylori infection. Eighty-four percent of the mothers reported at least one of the evaluated gastrointestinal symptoms, and 30% of the mothers reported at least one physician visit because of the severity of these symptoms. None of the analyzed gastrointestinal symptoms showed an association to a current H pylori infection after an adjustment for the covariates, even after a virulence marker of H pylori infection was taken into account.
CONCLUSION: This study does not support an involvement of H pylori infection in the generation of gastrointestinal symptoms during pregnancy.
Le texte complet de cet article est disponible en PDF.Keywords : Helicobacter pylori, gastrointestinal symptoms, pregnancy
Plan
 | Supported by grants of the Deutsche Forschungsgemeinschaft (BR 1704/3-1). |
Vol 189 - N° 2
P. 526-531 - août 2003 Retour au numéro
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