Vitamin C intake and the risk of preterm delivery - 28/08/11
Chapel Hill and Raleigh, NC
Abstract |
OBJECTIVE: Ascorbic acid deficiency may lead to premature rupture of the membranes.
STUDY DESIGN: The study included a prospective cohort of pregnant women, aged ≥16 years, with singleton gestations who received care at one of four prenatal clinics in central North Carolina from 1995 through 1998. Vitamin C intake preconceptionally and during the second trimester was examined for its association with preterm delivery and subsets of preterm labor, premature rupture of the membranes, and medical induction in 2064 women.
RESULTS: Women who had total vitamin C intakes of <10th percentile preconceptionally had twice the risk of preterm delivery because of premature rupture of the membranes (relative risk, 2.2; 95% CI, 1.1, 4.5). This risk was attenuated slightly for second-trimester intake (relative risk, 1.7; 95% CI, 0.8, 3.5). The elevated risk of preterm premature rupture of the membranes was greatest for women with a low vitamin C intake during both time periods.
CONCLUSION: Because diet and supplement use are modifiable behaviors, corroboration of these findings would suggest a possible intervention strategy.
Le texte complet de cet article est disponible en PDF.Keywords : Preterm birth, vitamin C, premature rupture of the membranes, diet, supplement
Plan
 | Supported by the National Institute of Child Health and Human Development, National Institutes of Health (grants No. HD28684 and HD05798), by the Institute of Nutrition, and by funds from the Wake Area Health Education Center in Raleigh, NC. Reprints not available from the authors. |
Vol 189 - N° 2
P. 519-525 - août 2003 Retour au numéro
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