Estrogen receptor expression in vulvar vestibulitis syndrome - 28/08/11
Reprint requests: A. B. MacLean, MD, FRCOG, Department of Obstetrics and Gynecology, Royal Free and University College Medical School (Royal Free Campus), Rowland Hill Street, London NW3 2PF, United KingdomAbstract |
OBJECTIVE: A pilot study was performed to investigate the relationship between vulvar vestibulitis syndrome and estrogen receptor expression.
STUDY DESIGN: Women with a diagnosis of vulvar vestibulitis syndrome had tissue samples taken for vulvar estrogen receptor-⍺ expression and this was compared with a control group.
RESULTS: The study group showed a significant decrease in estrogen receptor expression, and 50% of the samples did not exhibit any receptor expression.
CONCLUSION: There appears to be a subgroup of women with vulvar vestibulitis syndrome who exhibit abnormal estrogen receptor-⍺ expression. This may be helpful in explaining why some women are resistant to medical treatment and may allow treatment to be prescribed more effectively.
Le texte complet de cet article est disponible en PDF.Keywords : Vulvar vestibulitis syndrome, estrogen receptor
Plan
Vol 189 - N° 2
P. 458-461 - août 2003 Retour au numéro
Article précédent
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