Systemic and regional effects of supraceliac aortic occlusion during experimental hepatic vascular exclusion - 26/08/11
, Luiz F Poli de Figueiredo, M.D., Ph.D. a, Jose L.M Braz, M.D. a, Edna A Diniz, D.V.M. a, Mauricio Rocha e Silva, M.D., Ph.D. aAbstract |
Background |
Supraceliac aortic occlusion (AO) has been recommended to avoid hypotension during hepatic vascular exclusion (HVE). We hypothesized that AO may negatively affect splanchnic perfusion during HVE.
Methods |
Twenty-six dogs (16 ± 0.3 kg) were randomly assigned to HVE (n = 13) or HVE+AO (n = 13), during 30 minutes followed by a 60-minute reperfusion period. Cardiac output (CO), mean arterial pressure (MAP), superior mesenteric artery blood flow (SMABF, ultrasonic flowprobe), gastric mucosal PCO2 (gas tonometry) and PCO2-gap were evaluated.
Results |
HVE alone induced decreases in MAP from 115 ± 5.1 to 26 ± 1 mm Hg, in CO from 2.0 ± 0.1 to 0.4 ± 0.1 L/min and SMABF from 398 ± 42 to 16 ± 7.6 mL/min, while PCO2 gap increased from 4 ± 3.7 to 52 ± 5.4 mm Hg. Supraceliac aortic occlusion only avoided severe hypotension. During reperfusion MAP, CO, and SMABF were partially restored, while PCO2 gap showed no improvements in either group.
Conclusions |
HVE promotes major systemic and splanchnic perfusional derangement. Concomitant AO may avoid HVE-induced hypotension without producing further deleterious effects.
Le texte complet de cet article est disponible en PDF.Keywords : Aortic occlusion, Gastric tonometry, Hepatic vascular exclusion, Ischemia-reperfusion injury
Plan
Vol 185 - N° 4
P. 388-393 - avril 2003 Retour au numéro
Article précédent
- Reconstruction of the hepatic artery using the gastroduodenal artery
- Juan M Sarmiento, Jean M Panneton, David M Nagorney
- Intestinal fistulization in the open treatment of peritonitis
- Julian E. Losanoff, Bruce W. Richman, James W. Jones
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?