Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population - 26/08/11
, Takehito Hayakawa, PhD b, Takashi Kadowaki, MD a, Yoshikuni Kita, PhD a, Akira Okayama, MD c, Paul Elliott, FRCP d, Hirotsugu Ueshima, MD aNIPPONDATA80 Research Group†
Abstract |
Background |
Several prospective studies have reported resting heart rate (HR) to be a risk factor for certain cause-specific death, together with sex- or age-specific differences in the effects of HR on death. However, there have been few prospective data from non-Western populations.
Methods |
Cohort study, over 16.5 years to date of death or end of follow-up (November 15, 1998) involving 8800 men and women ≥30 years of age randomly selected throughout Japan, who participated in the National Survey on Circulatory Disorders in 1980. Resting HR was determined from 3 consecutive intervals between R waves on the 12-lead electrocardiogram.
Results |
For middle-aged men (30 to 59 years of age), in the highest quartile of HR, there was a significant positive association with cardiovascular (RR, 2.55; 95% CI, 1.22 to 5.31) and all-cause death (RR, 1.45; 95% CI, 1.06 to 2.00). For middle-aged women, in the highest quartile, there was a significant positive association with noncancer, noncardiovascular (RR, 2.41; 95% CI, 1.04 to 5.59), and all-cause death (RR, 1.94; 95% CI, 1.26 to 3.01). Resting HR also showed a significant positive association with cardiac events but not to stroke. These relations were not evident for elderly subjects (≥60 years of age). Results were not affected when deaths within the first 5 years of follow-up were excluded, except for noncancer, noncardiovascular death.
Conclusions |
High resting HR is an independent predictor of long-term death in the Japanese general population.
Le texte complet de cet article est disponible en PDF.Plan
 | Supported by the Research Grant for Cardiovascular Diseases (7A-2) from the ministry of Health and Welfare, Japan, and a Health and Labor Sciences Research Grant from the Ministry of Health, Labor and Welfare, Japan (Comprehensive Research on Aging and Health: H11-Chouju-046, H14-Chouju-003). |
Vol 147 - N° 6
P. 1024-1032 - juin 2004 Retour au numéro
Article précédent
- Coronary flow reserve abnormalities in patients with diabetes mellitus who have end-stage renal disease and normal epicardial coronary arteries
- Michael Ragosta, Habib Samady, Ross B Isaacs, Lawrence W Gimple, Ian J Sarembock, Eric R Powers
- Peroxisome proliferator-activated receptor-γ agonist rosiglitazone reduces circulating platelet activity in patients without diabetes mellitus who have coronary artery disease
- Jagdip S Sidhu, Dahlia Cowan, Jennifer A Tooze, Juan-Carlos Kaski
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?