Effect of oral l-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries - 26/08/11
Doi : 10.1016/j.amjcard.2003.12.040
Altin Palloshi, MD a, ⁎ 
, Gabriele Fragasso, MD a, PierMarco Piatti, MD b, Lucilla D. Monti, MD b, Emanuela Setola, MD b, Giampiero Valsecchi, PhD b, Elena Galluccio, PhD b, Sergio L. Chierchia, MD a, Alberto Margonato, MD a
, Gabriele Fragasso, MD a, PierMarco Piatti, MD b, Lucilla D. Monti, MD b, Emanuela Setola, MD b, Giampiero Valsecchi, PhD b, Elena Galluccio, PhD b, Sergio L. Chierchia, MD a, Alberto Margonato, MD a a Division of Clinical Cardiology, Milan, Italy
b Metabolic Unit, Istituto Scientifico San Raffaele, Milan, Italy
*Dr. Palloshi’s address is: Divisione di Cardiologia Clinica, Ospedale San Raffaele, Via Olgettina 60, 20132, Milan, Italy
Abstract |
Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral l-arginine (4 weeks, 2 g, 3 times daily). l-arginine significantly improved angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma l-arginine, l-arginine:asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral l-arginine may represent a useful therapeutic option.
Le texte complet de cet article est disponible en PDF. | The study was fully supported by Istituto Scientifico San Raffaele, Vita-Salute University, Milan, Italy. No other sources were used for this study. |
© 2004
Excerpta Medica Inc. Tous droits réservés.
Vol 93 - N° 7
P. 933-935 - avril 2004 Retour au numéro
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