Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers - 26/08/11

Doi : 10.1016/j.amjcard.2004.06.072

Daisuke Jitsuiki, MD ^a, Yukihito Higashi, MD, PhD ^a,⁎ , Chikara Goto, PhD ^a, Masashi Kimura, MD ^b, Kensuke Noma, MD ^b, Keiko Hara, MD ^b, Keigo Nakagawa, MD, PhD ^c, Tetsuya Oshima, MD, PhD ^d, Kazuaki Chayama, MD, PhD ^b, Masao Yoshizumi, MD, PhD ^a
^a Department of Cardiovascular Physiology and Medicine, Hiroshima University, Hiroshima, Japan
^b Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
^c Department of Developmental Biology, Hiroshima University, Hiroshima, Japan
^d Department of Clinical Laboratory Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan

^*Dr. Higashi's address is: Department of Cardiovascular Physiology and Medicine, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan

Résumé

The forearm blood flow (FBF) responses to acetylcholine and to sodium nitroprusside were evaluated before and after administration of edaravone in 10 smokers and 10 nonsmokers. FBF response to acetylcholine was lower in smokers than in nonsmokers. The vasodilatory effects of sodium nitroprusside were similar in both groups. Co-infusion of edaravone increased the FBF response to acetylcholine in smokers, but did not affect the FBF response to acetylcholine in nonsmokers. The administration of N^G-monomethyl-l-arginine abolished edaravone-induced augmentation of the FBF response to acetylcholine in smokers. The antioxidative agent edaravone increases nitric oxide mediated vasodilation through a decrease in oxidative stress.

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This study was supported in part by grants-in-aid 1559075100 and KOSEI151201 for scientific research from the Ministry of Education, Science and Culture of Japan, Tokyo, Japan.

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Vol 94 - N° 8

P. 1070-1073 - octobre 2004 Retour au numéro

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Effect of edaravone, a novel free radical scavenger, on endothelium-dependent vasodilation in smokers - 26/08/11

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