The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology - 26/08/11

Doi : 10.1016/S1472-9792(03)00051-9

T.C Terwilliger ^a,⁎ , M.S Park ^a, G.S Waldo ^a, J Berendzen ^b, L.-W Hung ^b, C.-Y Kim ^a, C.V Smith ^c, J.C Sacchettini ^c, M Bellinzoni ^d, R Bossi ^d, E De Rossi ^d, A Mattevi ^d, A Milano ^d, G Riccardi ^d, M Rizzi ^d, M.M Roberts ^e, A.R Coker ^f, G Fossati ^g, P Mascagni ^g, A.R.M Coates ^e, S.P Wood ^f, C.W Goulding ^h, M.I Apostol ^h, D.H Anderson ^h, H.S Gill ^h, D.S Eisenberg ^h, B Taneja ⁱ, S Mande ⁱ, E Pohl ^j, V Lamzin ^j, P Tucker ^j, M Wilmanns ^j, C Colovos ^j, W Meyer-Klaucke ^j, A.W Munro ^k, K.J McLean ^k, K.R Marshall ^k, D Leys ^k, J.K Yang ^l, H.-J Yoon ^l, B.I Lee ^l, M.G Lee ^l, J.E Kwak ^l, B.W Han ^l, J.Y Lee ^l, S.-H Baek ^l, S.W Suh ^l, M.M Komen ^m, V.L Arcus ^m, E.N Baker ^m, J.S Lott ^m, W Jacobs ⁿ, T Alber ^o, B Rupp ^p
^a Los Alamos National Laboratory, Bioscience Division, Mail Stop M888, Los Alamos, NM, 87545, USA
^b Los Alamos National Laboratory, Physics Division, Mail Stop D454, Los Alamos, NM 87545, USA
^c Department of Biochemistry and Biophysis, Texas A&M University, College Station, TX 77843-2128, USA
^d Department of Genetics and Microbiology, University of Pavia, Via Ferrata 1, 27100Pavia, Italy
^e Medical Microbiology, Department of Cellular and Molecular Medicine, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
^f Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
^g Italfarmaco Research Center, Via dei Lavoratori 54, 20092 Cinisello Balsamo, Milan, Italy
^h UCLA-DOE Lab of Structural Biology, Howard Hughes Medical Institute, Molecular Biology Institute, University of California, UCLA Box 951570, Los Angeles, CA 90095-1570, USA
ⁱ Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad-500076, India
^j EMBL Hamburg, c/o DESY, Notkestrasse 85, D-22603 Hamburg, Germany
^k Department of Biochemistry, University of Leicester, The Adrian Building, University Road, Leicester LE1 7RH, UK
^l Structural Proteomics Laboratory, School of Chemistry and Molecular Engineering, Seoul National University, Seoul 151-742, South Korea
^m Laboratory of Structural Biology, School of Biological Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
ⁿ Albert Einstein School of Medicine, Yeshiva University, Bronx NY 10461, USA
^o University of California, Berkeley, CA 94720, USA
^p Lawrence Livermore National Laboratory, Livermore, CA 94551, USA

^*Corresponding author

Abstract

The TB Structural Genomics Consortium is an organization devoted to encouraging, coordinating, and facilitating the determination and analysis of structures of proteins from Mycobacterium tuberculosis. The Consortium members hope to work together with other M. tuberculosis researchers to identify M. tuberculosis proteins for which structural information could provide important biological information, to analyze and interpret structures of M. tuberculosis proteins, and to work collaboratively to test ideas about M. tuberculosis protein function that are suggested by structure or related to structural information. This review describes the TB Structural Genomics Consortium and some of the proteins for which the Consortium is in the progress of determining three-dimensional structures.

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Keywords : Protein structure, X-ray crystallography, Structural genomics, Mycobacterium tuberculosis, Drug discovery