Catalase–peroxidase activity has no influence on virulence in a murine model of tuberculosis - 26/08/11
Abstract |
The capacity to generate a chronic and persistent infection in the experimental murine model of tuberculosis induced aerogenically by a low-dose inoculum was determined in eight isoniazid-resistant clinical strains of Mycobacterium tuberculosis showing different catalase–peroxidase (C–P) activities. Determination of bacillary concentration in lung and spleen and the percentage of pulmonary parenchyma occupied by granulomas were monitored. Data showed no relation between the lack of C–P activity and the ability to develop a persistent infection, highlighting the potential of C–P negative strains to spread through the community.
Le texte complet de cet article est disponible en PDF.Keywords : Tuberculosis, Murine model, Virulence, Catalase–peroxidase, Isoniazid
Plan
Vol 83 - N° 6
P. 351-359 - 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?