Management of metastatic malignant melanoma of the bladder - 26/08/11
Abstract |
Recombinant interleukin-2 (IL-2) has demonstrated antitumor activity and durable clinical responses in patients with metastatic melanoma. Careful screening and selection of appropriate patients has improved the safety profile of IL-2 administration. Gross hematuria would ordinarily preclude the safe delivery of IL-2. We report a case of metastatic melanoma to the bladder presenting with hematuria. A complete resection was performed and subsequently allowed the administration of high-dose, bolus IL-2. The combination of resection and IL-2 therapy resulted in a partial response maintained for more than 18 months. Symptomatic bladder melanoma should be aggressively treated to allow for systemic immunotherapy, which can provide durable responses.
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This work was supported by grants from the National Cancer Institute RO1 CA 093696 and the Doris Duke Charitable Foundation T98052. |
Vol 62 - N° 2
P. 351 - août 2003 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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