Synergistic effects of Cox-1 and -2 inhibition on bladder and prostate cancer in vitro - 25/08/11
Abstract |
Background |
We hypothesized that combined treatment with cyclooxygenase (Cox)-1 (catechin) and Cox-2 (NS398)–specific inhibitors would reduce cellular proliferation synergistically in genitourinary cancer.
Methods |
Bladder (T24 and TCCSUP) and prostate (DU145, LnCaP, and PC3) cancer cell lines were treated with catechin and NS398 at a dose of 100 μmol/L as single and combined treatments. Viability was measured by MTT assay at 24 and 72 hours.
Results |
Significant synergism of Cox-1 and Cox-2 inhibitors was observed in both bladder cancer lines at both 24 and 72 hours. Synergism of Cox-1 and -2 inhibitors also was noted in the DU145 cells at 72 hours, LnCap cells at 24 hours, and PC3 at both 24 and 72 hours.
Conclusions |
Significant synergistic effects exhibited by the combination of Cox-1 and Cox-2 inhibitors suggest that these could become a highly effective treatment modality for carcinoma of both the bladder and prostate.
Le texte complet de cet article est disponible en PDF.Keywords : Apoptosis, Bladder, Cox-1 inhibitor, Cox-2 inhibitor, Prostate
Plan
Vol 188 - N° 5
P. 505-510 - novembre 2004 Retour au numéro
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