Association between TLR3 gene variants and Japanese cedar pollinosis - 25/08/11
Abstract |
Rationale |
The purpose of this study was to investigate whether the genetic variants of Toll-like receptor (TLR) 3 relate to Japanese cedar pollinosis (JCPsis), a most important springtime allergic rhinitis in Japan.
Methods |
We performed a case-control association study among a Japanese population, involving 95 unrelated adults individuals with JCPsis and 95 normal healthy controls. 4 SNPs (-8921A/T, -8441T/A and -7C/A in the 5' genomic region, and 6444C/T in exon 4) at the human TLR3 locus were genotyped using PCR-RFLP or direct sequencing.
Results |
The 6444C/T polymorphism was significantly associated with JCPsis (P=0.0098; OR=2.26; 95% CI, 1.21–4.22). Significant association was also found between 6444C/T polymorphism and JCPsis-related phenotypes including clinical severity, serum total and allergen-specific IgE levels, and eosinophil counts in nasal secretion.
Conclusions |
The 6444C/T polymorphism in the TLR3 gene is associated with susceptibility to rhinitis due to Japanese cedar pollen, but the functional relationship still needs clarification.
Le texte complet de cet article est disponible en PDF. | Funding: Japanese Millennium Genome Project |
Vol 113 - N° 2S
P. S25 - février 2004 Retour au numéro
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