Individuals with cow's milk allergy are sensitized to milk from deer and ibex but not to milk from pork. Is there a “kosher” epitope? - 25/08/11
Abstract |
Rationale |
There is almost a complete cross reactivity between cow's milk allergy (CMA) and allergy to milk from goat, ewe and buffalo, all “kosher” animals but no cross reactivity to milk from camel and mare, all “non Kosher”. Here cross reactivity between sensitization to cow's milk and sensitization to milk from deer, ibex (“Kosher”) and pork were tested.
Methods |
Thirty patients, aged 4 weeks to 30 years, 23 with CMA with typical history and positive skin prick test (SPT) and 7 without CMA were studied. SPT to Cow's milk, and milk from the following: deer, ibex, pork, buffalo, and to histamine and negative control were performed.
Results |
Among the 23 patients with CMA all 23 reacted to deer's milk, 21/21 reacted to ibex, 4/21 to pork and 21/21 to buffalo. Among the seven patients without CMA none reacted to any of the SPT except for the histamine. Spearman's rho correlation coefficient between CMA and deer and ibex's milk sensitization were 1 (p=0) and between cow's milk to pork's milk was 0.269, non significant (p=0.162).
Conclusions |
We assume that milk proteins originated from cow, deer and ibex share a common epitope (or epitopes). If one wishes to draw conclusions regarding clinical allergy an oral challenge has to be carried out.
Le texte complet de cet article est disponible en PDF. | Funding: Self-funded |
Vol 113 - N° 2S
P. S156 - février 2004 Retour au numéro
Article précédent
- Cross-reactivity of walnut, cashew, and hazelnut legumin proteins in tree nut allergic patients
- M.L. Wallowitz, S. Teuber, K. Beyer, H.A. Sampson, K.H. Roux, S.K. Sathe, F. Wang, J. Robotham
- Th1/Th2 T cell sensitivity to rice in an infant
- H.C. Gray, B.A. Becker, A.P. Knutsen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?