Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia - 25/08/11
, Andrea S. Lukes, MD a, Leo R. Brancazio, MD a, Elizabeth Thames, BS b, Thomas L. Ortel, MD, PhD b
Reprint requests: Andra H. James, MD, MPH, Division of Maternal and Fetal Medicine, Box 3967, Duke University Medical Center, Durham, NC 27710.Abstract |
Objective |
The purpose of this study was to assess the usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia.
Study design |
Women with menorrhagia and control subjects were tested with a platelet function analyzer. If the results were abnormal, further testing was performed for possible von Willebrand disease or platelet dysfunction. Results were compared.
Results |
Of the 108 women with menorrhagia, 28 had an abnormal platelet function analysis results: 7 results were suggestive of von Willebrand disease; 17 results were suggestive of platelet dysfunction, and 4 results were inconclusive. Of the 100 control subjects, 18 subjects had an abnormal platelet function analysis result: 2 results were suggestive of von Willebrand disease; 12 results were suggestive of platelet dysfunction, and 4 results were inconclusive. The prevalence of suspected von Willebrand disease was 6% among women with menorrhagia and 2% among control subjects. Among white women, the prevalence was 10% compared with 1% among control subjects.
Conclusion |
We demonstrated that the platelet function analyzer could be used to detect von Willebrand disease in women with menorrhagia.
Le texte complet de cet article est disponible en PDF.Keywords : Menorrhagia, von Willebrand disease, Platelet function analyzer
Plan
 | Supported in part by a grant from Dade-Behring, Inc. |
Vol 191 - N° 2
P. 449-455 - août 2004 Retour au numéro
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