Eyelid bleeding and atypical amyloidosis - 25/08/11
, Eyal Aloni, MD a, Asher Milshtein, MD a, Arie Marcovich, MD a, Marta Mozes, MD b, Ayala Pollack, MD aAbstract |
Purpose |
To describe a case of atypical systemic amyloidosis in a patient who presented with recurrent subcutaneous bleeding of the eyelids and auricles.
Design |
Observational case report.
Methods |
A 52-year-old man with chronic cardiac failure, hypertension, weight loss, and impotence presented with recurrent bleeding of the eyelids and auricles, and was investigated for suspected amyloidosis.
Results |
Biopsy specimens taken from the bone marrow, salivary gland, abdominal subcutaneous fat, and gastric mucosa, and eyelids were all negative for Congo red. Results of a conjunctival biopsy, which were returned after the patient's death, and cardiac muscle autopsy were positive for Congo red staining, indicating amyloidosis.
Conclusion |
The findings in this case show that the presentation of amyloidosis may be atypical. Ophthalmologists should consider a diagnosis of amyloidosis in patients with periorbital bleeding, even if biopsies are negative for Congo red. A conjunctival biopsy may be useful in establishing a diagnosis of primary systemic amyloidosis.
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Vol 138 - N° 3
P. 495-496 - septembre 2004 Retour au numéro
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