The effects of repeated spectroscopic pressure measurements on fluorescence intensity in the cervix - 25/08/11
Reprint requests to: Michele Follen, MD, PhD, The University of Texas M. D. Anderson Cancer Center, Unit 193, 1515 Holcombe Blvd, Houston, TX 77030.Résumé |
Objective |
Fluorescence spectroscopy is a promising technology for the detection of cervical squamous intraepithelial lesions (SILs). In this study we took repeated measures in the cervix to determine whether the order of measurement produces changes in fluorescence intensity and whether there are differences in variation due to pressure.
Methods |
A pressure sensitive fiber-optic probe to measure fluorescence spectra was calibrated at light, medium, and firm levels (0.2, 0.4, 0.6 N). Measurements were made 3 times at each of 2 sites in the patient's cervix. Spectroscopic data were preprocessed and analyzed to compare order of pressure and intensity variability as a function of pressure on measurements.
Results |
Four providers took 3 measurements from 2 sites each in 18 patients, yielding 108 measurements. After corrections for multiple comparisons, neither the order of probe pressure nor the variability of probe pressure significantly affected variations in fluorescence intensity.
Conclusion |
This study shows that the probe pressure variability is probably not an issue for these devices.
Le texte complet de cet article est disponible en PDF.Key words : Fluorescence intensity, Spectroscopy, Fiber-optic probe, Probe pressure
Plan
| Supported by the National Cancer Institute, Program Project Grant PO1 CA 82710-04. |
Vol 191 - N° 5
P. 1606-1617 - novembre 2004 Retour au numéro
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