Interferon-γ expression is an independent prognostic factor in ovarian cancer - 25/08/11
, Heidi Fiegl, PhD a, Alain G. Zeimet, MD, PhD a, Elisabeth Müller-Holzner, MD, PhD a, Martina Deibl, MS b, Wolfgang Doppler, PhD c, Günter Daxenbichler, PhD a
Reprint requests: Christian Marth, MD, PhD, Department of Obstetrics and Gynecology, Innsbruck Medical University Hospital, Anichstrasse 35, A-6020 Innsbruck, Austria.Abstract |
Background |
Epithelial ovarian cancer prognosis is improved by the presence of intratumoral CD3+ T cells, which are known to produce interferon-γ. We therefore speculated that interferon-γ expression in ovarian cancer-infiltrating T-lymphocytes might cause better prognosis.
Patients and methods |
Reverse transcriptase polymerase chain reaction was performed to measure the expression of interferon-γ and other related genes in normal ovaries (n=19) and in ovarian cancer specimens (n=99). Median follow-up of patients was 5.8 years.
Results |
Interferon-γ and CD-3 expression did not significantly differ in normal and malignant tissue. Patients with high levels of interferon-γ expression had significantly longer progression-free and overall survival. Median time to progression was 10 and 29 months for patients with low and high interferon-γ expression, respectively (P=.039). Corresponding survival times were 29 and 44 months (P < .032). Application of multivariate Cox regression analysis showed interferon-γ expression to be an independent prognostic factor for progression-free and overall survival.
Conclusion |
Elevated interferon-γ expression correlates with improved clinical outcome in patients with ovarian cancer.
Le texte complet de cet article est disponible en PDF.Key words : Interferon-γ, Ovarian cancer, Cancer immunology, Chemotherapy
Plan
Vol 191 - N° 5
P. 1598-1605 - novembre 2004 Retour au numéro
Article précédent
- Hybrid capture 2 viral load and the 2-year cumulative risk of cervical intraepithelial neoplasia grade 3 or cancer
- Philip E. Castle, Mark Schiffman, Cosette M. Wheeler
- The effects of repeated spectroscopic pressure measurements on fluorescence intensity in the cervix
- Kelley Rivoire, Audrey Nath, Dennis Cox, E. Neely Atkinson, Rebecca Richards-Kortum, Michele Follen
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?