Does metformin induce ovulation in normoandrogenic anovulatory women? - 25/08/11
Reprint requests: Rogerio A. Lobo, MD, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 622 W 168th St, New York, NY 10032.Abstract |
Objective |
This study was undertaken to evaluate the efficacy of metformin in women with anovulation who do not have evidence for hyperandrogenism and classic polycystic ovary syndrome.
Study design |
A randomized trial of metformin (1500 mg daily) and placebo in 24 anovulatory women was undertaken for 3 months. Assessments of changes in hormone levels and insulin sensitivity were carried out. Abnormal hormonal values were defined by levels exceeding the range in normal ovulatory controls.
Results |
Anovulatory women had normal androgen levels and luteinizing hormone but had higher serum insulin and lower insulin sensitivity compared with controls. Over 3 months, there were 16 ovulatory cycles with metformin and only 4 with placebo (P < .05). Success of ovulation did not correlate with changes in androgen, insulin, or insulin sensitivity parameters.
Conclusion |
Metformin may be useful for inducing ovulation in anovulatory women who do not have hyperandrogenism. This effect may be independent of a lowering of androgen or insulin levels.
Le texte complet de cet article est disponible en PDF.Key words : Anovulation, Infertility, Metformin
Plan
Vol 191 - N° 5
P. 1580-1584 - novembre 2004 Retour au numéro
Article précédent
- Acupuncture for labor pain management: A systematic review
- Hyangsook Lee, Edzard Ernst
- NovaSure impedance controlled system for endometrial ablation: Three-year follow-up on 107 patients
- Adolf Gallinat
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?