Enterovirus-related type 1 diabetes mellitus and antibodies to glutamic acid decarboxylase in Japan - 24/08/11
, Toshiaki Ihara b, Hiroaki Ioi a, Shingo Oana a, Satoshi Sato a, Naoki Kato a, Takeshi Takami a, Yasuyo Kashiwagi a, Kouji Takekuma a, Akinori Hoshika a, Takayuki Mori c
Corresponding author. Tel.: +81-3-3342-6111; fax: +81-3-3344-0643Abstract |
Objectives. In order to clarify the relationship between enteroviruses and type 1 diabetes mellitus in Japan we investigated enteroviral RNA in serum from children with type 1 diabetes mellitus.
Methods. We investigated enteroviral RNA in serum from children with type 1 diabetes mellitus by using highly sensitive RT-PCR. Additionally the sequences and viral loads were determined and compared with anti-coxsackie virus antibodies and anti-glutamic acid decarboxylase (GAD) antibodies.
Results. RT-PCR for enterovirus was positive in 23 (37.7%) from 61 samples. The positivity had no disparity of age, but decreased by aging after the occurrence of type 1 diabetes mellitus. The sequences of the positives were similar as those of coxsackie B4. The viral loads revealed that there was no positive patient with high titers of anti-GAD antibodies.
Conclusion. In Japan there is some correlation with type 1 diabetes mellitus and enterovirus. The pathophysiology of type 1 diabetes mellitus seems to consist of a direct destruction by persistent coxsackie virus and the autoimmune mechanism through autoantibodies against beta-cells.
Le texte complet de cet article est disponible en PDF.Keywords : Enterovirus, Coxsackie virus, Type 1 diabetes mellitus, Glutamic acid decarboxylase, Quantification, Children
Plan
Vol 49 - N° 2
P. 147-151 - août 2004 Retour au numéro
Article précédent
- Could neonatal disseminated herpes simplex virus infections be treated earlier?
- Katy J Fidler, Christine M Pierce, W.David Cubitt, Vas Novelli, Mark J Peters
- Characteristics and geographical profile of strongyloidiasis in healthcare area 11 of the Valencian community (Spain)
- Carles Oltra Alcaraz, Rafael Igual Adell, Pilar Sánchez Sánchez, Maria José Viñals Blasco, Oscar Andreu Sánchez, Antonio Sarrión Auñón, David Rodrı́guez Calabuig
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?