Perception of risk associated with asthma research procedures among adolescents, parents, and pediatricians - 24/08/11
, Janet L. Brody, PhD b, David G. Scherer, PhD c, Elizabeth A. Perkett, MD a
Reprint requests: Robert D. Annett, PhD, Department of Pediatrics, MSC-10-5590, 1 University of New Mexico, Albuquerque, NM, 87131-0001.Albuquerque, NM, and Eugene, Ore
Abstract |
Background |
Little empirical data exist about how adolescents with asthma, their parents, and pediatricians view the risks and benefits associated with asthma clinical research.
Objective |
Two studies examined similarities and differences in the perception of risks and benefits associated with asthma research.
Methods |
In study I questionnaires were completed by adolescents with asthma and parents at the end of an audio and written presentation of a hypothetical research vignette. In study II adolescents with asthma, their parents, and pediatricians rated the risks and benefits associated with discreet asthma research procedures.
Results |
In study I adolescents and parents made distinctions in riskiness among the asthma research procedures (P < .001 and P < .001, respectively). With the exception of venipuncture, rank orders of risk ratings among procedures were similar for both groups. In study II significant differences in risk and benefit ratings for individual procedures were found among respondent groups, including experimental medication, placebo, and venipuncture. Overall, asthma research procedures were viewed as more beneficial than risky (P < .001).
Conclusion |
Participants generally viewed asthma research procedures as more beneficial than risky. Overall, the relative risk rankings among all respondents were similar. However, there were between-group difference in ratings of risk associated with venipuncture and experimental medication. Parents and adolescents rated the benefit of placebo significantly higher than did pediatricians.
Le texte complet de cet article est disponible en PDF.Key words : Bioethics, risk-benefit evaluation
Abbreviations used : FDA, IRB, MANOVA
Plan
| Supported by the Department of Health and Human Services, National Heart, Lung, and Blood Institute (NHLBI-RO1-HL64677). |
Vol 114 - N° 5
P. 1138-1145 - novembre 2004 Retour au numéro
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