Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population - 24/08/11
, Florentino Sánchez-García, MD, PhD b, María-José Torres-Galván, PhD c, Antonio G. Dumpierrez, MD a, Lourdes Almeida, MD a, Javier Figueroa, MD a, Nancy Ortega, MD a, Rodolfo Castillo, MD, PhD a, María-Dolores Gallego, MD a, Teresa Carrillo, MD, PhD a
Reprint requests: Carlos Blanco, MD, PhD, Servicio de Alergia, Hospital de Gran Canaria Dr Negrín, C/Bco de la Ballena s/n, 35012 Las Palmas de GC, Spain.Canary Islands, Spain
Abstract |
Background |
The latex-fruit syndrome is a well-defined disorder whose genetic background has not been elucidated.
Objective |
To study the genetic basis of the latex-fruit syndrome.
Methods |
In a case-control study, we have investigated a carefully selected group of patients allergic to latex, searching for association between latex-fruit allergy and HLA class I and II genes, HLA-DR functional groups, and markers IL4-R1 and FcεRI-βca.
Results |
Seventy-eight patients allergic to latex without spina bifida, 33% of them also allergic to fruits, were included in our protocol. Skin prick test results with both a commercial latex extract and purified hevein were significantly greater in patients allergic to latex and fruit than in patients allergic to latex and not fruit. A cutoff point of >7 mm for commercial latex skin prick test diagnosed latex-fruit allergy with a sensitivity of 66.7% (95% CI, 41.0-86.6) and a specificity of 83.3% (95% CI, 68.6-93.0) in our series of patients. No significant differences were found regarding HLA class I, IL4-R1, or FcεRI-βca allele distributions. However, comparison of HLA class II allelic frequencies between patients allergic to latex and fruit and patients allergic to latex and not fruit showed significant associations of latex-fruit allergy with DQB10201 (corrected P value, .001; odds ratio, 7.3; 95% CI, 2.6-20.0), as well as with HLA-DR functional group E (corrected P value, .028; odds ratio, 16.0; 95% CI, 1.9-134.1). When comparing allelic distribution among different subgroups of patients allergic to latex, additional significant associations of latex-fruit allergy with DRB10301 and 0901, and of latex and not fruit allergy with DQB10202, DRB10701 and 1101, were demonstrated.
Conclusions |
Latex-fruit allergy is associated with HLA-DQB10201, DRB10301, and 0901, as well as with HLA-DR functional group E, whereas latex–not-fruit allergy is associated with DQB10202, and with both DRB10701 and 1101 alleles.
Key words : Latex allergy, latex-fruit syndrome, hevein, HLA, microsatellite
Abbreviations used : OR, Pc, ROC, SPT, SSO
Plan
| Partially supported by Instituto de Salud Carlos III (Fondo de Investigaciones Sanitarias grant 00/1019, ISCiii-RTIC-G03/094, and RedRespira-ISCiii-RTIC-C03/11), and by Fundación de la Sociedad Española de Alergología e Inmunología Clínica. |
Vol 114 - N° 5
P. 1070-1076 - novembre 2004 Retour au numéro
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