Generic and additional names: Thioridazine; 2-methylmercapto-10-[2-(N-methyl-2-piperidyl)ethyl]phenothiazine; 3-methylmercapto-N-[2′-(N′-methyl-2-piperidyl)ethyl]phenothiazine; Thioridazine-2-sulfoxide

CAS name: 10-[2-(1-Methyl-2-piperidinyl)ethyl]-2-(methylthio)-10H-phenothiazine

CAS registry #: 50-52-2

Molecular formula: C₂₁H₂₆N₂S₂

Molecular weight: 370.57

Intellectual property rights: Generic

Brand names: Aldazine (Alphapharm); Mellaril, Melleretten, Mallorol (Novartis); Novoridazine (Novopharm); Orsanil (Orion); Ridazin (Taro); Stalleril (Pharmacal)

Solubility: Soluble in alcohol (1 in 6), chloroform (1 in 0.81), ether (1 in 3); freely soluble in dehydrated alcohol; practically insoluble in water at 0.0336 mg/l [Merck Index].

Polarity: Log P 6.552 [DrugBank]

Acidity/basicity: pKa 9.5 [DrugBank].

Melting point: 73ºC [DrugBank]

Formulation and optimal human dosage: The usual starting dose for adult schizophrenic patients is 50–100 mg three times a day, with a gradual increment to a maximum of 800 mg daily if necessary. Supplied as oral suspension or as tablets from 10 to 200 mg. Some phenothiazines can be administered i.v.