Generic and additional names: Linezolid

CAS name: N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

CAS registry #: 165800-03-3

Molecular formula: C₁₆H₂₀FN₃O₄

Molecular weight: 337.35

Intellectual property rights: Pfizer

Brand names: Zyvox, Zyvoxid (Pfizer)

Derivatives: Dong-A Pharmaceutical has reported several new oxazolidinones (DA-7157, DA-7218 and DA-7867) having somewhat improved in-vitro potency, compared to linezolid, against Mycobacterium tuberculosis, M. kansasii and M. marinum^1,2

Solubility: In water up to 3 mg/ml [DrugBank]

Polarity: Log P 0.232 [DrugBank]

Melting point: 181.5 182.5ºC [Merck Index]

Formulation and optimal human dosage: Zyvox tablets for oral administration contain 400 mg or 600 mg linezolid.

Zyvox i.v. injection is supplied as a 2 mg/ml isotonic solution for intravenous infusion.

Doses: oral or i.v. 600 mg every 12 hours for serious infections and 400 mg every 12 hours for uncomplicated infection [FDA label].