Isoniazid - 23/08/11
Résumé |
Generic and additional names: isonicotinic acid hydrazide; isonicotinoylhydrazine; isonicotinylhydrazine; INH; rimitsid; tubazid
CAS name: pyridine-4-carbohydrazide
CAS registry #: 54-85-3
Molecular formula: C6H7N3O
Molecular weight: 137.14
Intellectual property rights: Generic. First synthesized in 1912, first used clinically in 1952.
Brand names: Cotinazin (Pfizer); Dinacrin (Winthrop); Ditubin (Schering); Hycozid (Takeda); Iscotin (Daiichi); Isobicina (Maggioni); Isocid (CID); Isolyn (Abbott); Isonex (Dumex); Isonizida (Bial); Isozid (Fatol); Laniazid (Lannett); Mybasan (Antigen); Neoteben (Bayer); Nicizina (Pfizer); Niconyl (Parke-Davis); Nicotibina (Lapetit); Nydrazid (Bristol-Myers Squibb); Pycazide (Smith & Nephew); Pyricidin (Nepera); Rimifon (Roche); Tibinide (Ferrosan); Tubilysin (Orion)
Derivatives: Isoniazid 4-aminosalicylate
Isoniazid 4-pyridinecarboxylic acid 2-(sulfomethyl) Isoniazid methanesulfonate sodium (derivative)
Solubility: Solubility in water: 14% at 25ºC, 26% at 40ºC; in ethanol: 2% at 25ºC, 10% in boiling ethanol; in chloroform: 0.1%. Practically insoluble in ether, benzene [Merck Index].
Polarity: Log P −0.64
Acidity/basicity: pH of a 1% aqueous solution 5.5 to 6.5 [Merck Index]
Melting point: 171.4ºC [DrugBank]
Formulation and optimal human dosage: 5 mg/kg for adults, 10–20 mg/kg for children. Adult dosing generally 300 mg capsule administered orally, once daily; or 15 mg/kg up to 900 mg/day, two or three times/week, ideally dose administered one hour before or two hours after a meal. Concomitant administration of pyridoxine (B6) recommended for malnourished patients, adolescents, and those predisposed to neuropathy (e.g. diabetic).
Can also be given intramuscularly or intravenously [DrugBank].
Vol 88 - N° 2
P. 112-116 - mars 2008 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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