Generic and additional names: Ethionamide

CAS name: 2-Ethyl-4-pyridinecarbothioamide

CAS registry #: 536-33-4

Molecular formula: C₈H₁₀N₂S

Molecular weight: 166.24

Intellectual property rights: Generic

Brand names: Trecator (Wyeth); Nisotin; Trescatyl (M&B); Aetina; Ethimide; Iridocin (Bayer); Tio-Mid

Derivatives: Prothionamide is the propyl analog of ethionamide

Solubility: Very sparingly soluble in water, ether. Sparingly soluble in methanol, ethanol, propylene glycol.

Soluble in hot acetone, dichloroethane. Freely soluble in pyridine [Merck Index].

Polarity: Log P 0.705 [DrugBank]

Melting point: 163ºC [DrugBank]

Formulation and optimal human dosage: Supplied in 250 mg tablets, recommended dose 750 mg orally

[FDA label]

Therapy is usually initiated at 250 mg daily, with gradual titration to optimal doses as tolerated by the patient. A regimen of 250 mg daily for 1 or 2 days, followed by 250 mg twice daily for 1 or 2 days with a subsequent increase to 1 g in 3 or 4 divided doses has been reported [FDA label].