Cycloserine - 23/08/11
Résumé |
Generic and additional names:d-4-Amino-3-isoxazolidone; orientomycin
CAS name:d-4-Amino-3-isoxazolidinone
CAS registry #: 68-41-7
Molecular formula: C3H6N2O2
Molecular weight: 102.09
Intellectual property rights: Generic, marketed 1952
Brand names: Closina; Farmiserina (Farmitalia); Micoserina; Oxamycin (Merck & Co.); Seromycin (Lilly)
Solubility: Soluble in water, slightly soluble in methanol, propylene glycol. Forms salts with acids and bases [Merck Index].
Polarity: Log P −1.631 [DrugBank]
Acidity/basicity: Aqueous solutions have a pH around 6 [Merck Index]
Stability: Neutral or acid solutions are unstable. Aqueous solutions buffered to pH 10 with sodium carbonate can be stored without loss for one week at +4ºC [Merck Index].
Melting point: 147ºC [DrugBank]
Formulation and optimal human dosage: 250 mg tablet, dose is 500–750 mg daily1
Vol 88 - N° 2
P. 100-101 - mars 2008 Retour au numéro
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