Many techniques exist for treating rhytids in the perioral region. Injectable fillers, Botox, implants, lip lifts, and lip advancements all produce lasting results. Resurfacing procedures can also be used to rejuvenate this area. This article discusses the use of chemical peels, dermabrasion, and laser resurfacing, alone or in combination, as methods to reduce fine and vertical rhytids of the upper and lower lips and superficial scarring in the perioral region. The authors emphasize that the best outcomes are often achieved using a combination of these modalities tailored to each patient’s needs, which also allows surgeons greater flexibility in achieving maximal results. This article also discusses patient selection, counseling, planning, and techniques that have yielded consistent results with high patient satisfaction.