Regulation of the Mycobacterium tuberculosis PE/PPE genes - 22/08/11

Doi : 10.1016/j.tube.2003.12.014

M.I. Voskuil ^a,^b,⁎ , D. Schnappinger ^c, R. Rutherford ^d, Y. Liu ^b, G.K. Schoolnik ^b
^a Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
^b Division of Infectious Diseases and Geographic Medicine, Department of Medicine and Department of Microbiology and Immunology, Stanford Medical School, Stanford, CA 94305, USA
^c Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
^d Department of Biology, Saint Olaf College, Northfield, MN 55057, USA

^*Corresponding author. Department of Microbiology, B175, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA. Tel.: +1-303-315-2326; fax: +1-303-315-6785

Abstract

The genome of Mycobacterium tuberculosis encodes approximately 170 members of the unique mycobacterial PE and PPE gene families. Evidence suggests members of these families are surface-associated cell wall proteins that may provide a diverse antigenic profile and affect immunity. To determine if the expression patterns of PE/PPE genes are consistent with a role in antigenic variability, we analyzed microarray data from 132 experimental conditions for expression of PE/PPE genes. Whole genome expression patterns show that the PE/PPE genes are regulated in a variable and largely independent manner. Gene expression profiling of 15 unique conditions identified differential regulation of 128 of the 169 PE/PPE genes. Expression of the PE/PPE genes appears to be controlled by a variety of independent mechanisms. These data indicate that differential expression of the PE/PPE genes has the potential to provide a dynamic antigenic profile during the course of changing microenvironments within the host.

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Keywords : Mycobacterium tuberculosis, PE, PPE, Microarray

Plan

PE/PPE gene expression profiles

Response of PE/PPE genes to environmental change

Conclusions

Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.tube.2003.12.014

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Vol 84 - N° 3-4

P. 256-262 - 2004 Retour au numéro

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Regulation of the Mycobacterium tuberculosis PE/PPE genes - 22/08/11

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